. 16 Assessing tibiofemoral contact forces has been suggested as an essential approach to understand the initiation and progression of knee injuries and diseases. 18 Computer-simulated musculoskeletal models are often used to estimate tibiofemoral contact forces during various movements. 19 , 20
Yumeng Li, He Wang and Kathy J. Simpson
Hans Kainz, Hoa X. Hoang, Chris Stockton, Roslyn R. Boyd, David G. Lloyd and Christopher P. Carty
Gait analysis together with musculoskeletal modeling can be used to assess pathological gait, 1 predict musculoskeletal loading, 2 and evaluate the outcome of clinical interventions. 3 The model used for musculoskeletal analyses can be created directly from medical images 4 or
R. Tyler Richardson, Elizabeth A. Rapp, R. Garry Quinton, Kristen F. Nicholson, Brian A. Knarr, Stephanie A. Russo, Jill S. Higginson and James G. Richards
Musculoskeletal modeling is capable of estimating physiological parameters that cannot be directly measured, 1 , 2 however, the validity of the results must be assessed. A substantial challenge of modeling the shoulder lies in proper implementation of scapular kinematics. 3 , 4 Scapular
Zachary F. Lerner, Derek J. Haight, Matthew S. DeMers, Wayne J. Board and Raymond C. Browning
Net muscle moments (NMMs) have been used as proxy measures of joint loading, but musculoskeletal models can estimate contact forces within joints. The purpose of this study was to use a musculoskeletal model to estimate tibiofemoral forces and to examine the relationship between NMMs and tibiofemoral forces across walking speeds. We collected kinematic, kinetic, and electromyographic data as ten adult participants walked on a dual-belt force-measuring treadmill at 0.75, 1.25, and 1.50 m/s. We scaled a musculoskeletal model to each participant and used OpenSim to calculate the NMMs and muscle forces through inverse dynamics and weighted static optimization, respectively. We determined tibiofemoral forces from the vector sum of intersegmental and muscle forces crossing the knee. Estimated tibiofemoral forces increased with walking speed. Peak earlystance compressive tibiofemoral forces increased 52% as walking speed increased from 0.75 to 1.50 m/s, whereas peak knee extension NMMs increased by 168%. During late stance, peak compressive tibiofemoral forces increased by 18% as speed increased. Although compressive loads at the knee did not increase in direct proportion to NMMs, faster walking resulted in greater compressive forces during weight acceptance and increased compressive and anterior/posterior tibiofemoral loading rates in addition to a greater abduction NMM.
Amy R. Lewis, William S.P. Robertson, Elissa J. Phillips, Paul N. Grimshaw and Marc Portus
Optimization of propulsion technique for both performance and injury risk can be achieved using musculoskeletal modeling approaches, which can take into account athlete-specific physical attributes. The limiting factor of this approach, however, is the inherent reliance on the quality of input parameters
Antoine Falisse, Sam Van Rossom, Johannes Gijsbers, Frans Steenbrink, Ben J.H. van Basten, Ilse Jonkers, Antonie J. van den Bogert and Friedl De Groote
Musculoskeletal models for biomechanical simulations have become increasingly popular to analyze human movement. In addition to joint kinematics and kinetics, musculoskeletal models enable researchers and clinicians to assess other biomechanical variables, such as muscle lengths and forces
Nathalie Alexander and Hermann Schwameder
While inclined walking is a frequent daily activity, muscle forces during this activity have rarely been examined. Musculoskeletal models are commonly used to estimate internal forces in healthy populations, but these require a priori validation. The aim of this study was to compare estimated muscle activity using a musculoskeletal model with measured EMG data during inclined walking. Ten healthy male participants walked at different inclinations of 0°, ± 6°, ± 12°, and ± 18° on a ramp equipped with 2 force plates. Kinematics, kinetics, and muscle activity of the musculus (m.) biceps femoris, m. rectus femoris, m. vastus lateralis, m. tibialis anterior, and m. gastrocnemius lateralis were recorded. Agreement between estimated and measured muscle activity was determined via correlation coefficients, mean absolute errors, and trend analysis. Correlation coefficients between estimated and measured muscle activity for approximately 69% of the conditions were above 0.7. Mean absolute errors were rather high with only approximately 38% being ≤ 30%. Trend analysis revealed similar estimated and measured muscle activities for all muscles and tasks (uphill and downhill walking), except m. tibialis anterior during uphill walking. This model can be used for further analysis in similar groups of participants.
John W. Chow, Warren G. Darling and James C. Ehrhardt
The purpose of this study was to determine the maximum muscle stress (σ), defined as the maximum isometric force divided by the physiological cross-sectional area, of the quadriceps muscles for a pilot study involving musculoskeletal modeling. One female subject performed maximum effort isometric knee extension exercises on an isokinetic dynamometer at different attachment arm angles. The gravitational effect was taken into consideration when determining the isometric resultant knee torques at different knee flexion angles. The anatomical and geometric parameters of the quadriceps muscles were obtained from radiography and magnetic resonance imaging taken from the subject. The σ value was computed using me measured knee torques, musculoskeletal parameters data, and information reported in the literature. The computation procedures used in this study represented the first attempt to incorporate the concept of optimal muscle length in the determination of maximum muscle stress. The σ values obtained from the data for nine different knee flexion angles ranged from 21.4 to 30.5 N/cm2. The average value of 25.6 ± 2.6 N/cm2 is notably smaller than the human σ values reported in the literature, but is comparable to the σ values obtained from isolated muscles.
Amy K. Hegarty, Max J. Kurz, Wayne Stuberg and Anne K. Silverman
The goal of this pilot study was to characterize the effects of gait training on the capacity of muscles to produce body accelerations and relate these changes to mobility improvements seen in children with cerebral palsy (CP). Five children (14 years ± 3 y; GMFCS I-II) with spastic diplegic CP participated in a 6-week gait training program. Changes in 10-m fast-as-possible walking speed and 6-minute walking endurance were used to assess changes in mobility. In addition, musculoskeletal modeling was used to determine the potential of lower-limb muscles to accelerate the body’s center of mass vertically and forward during stance. The mobility changes after the training were mixed, with some children demonstrating vast improvements, while others appeared to be minimal. However, the musculoskeletal results revealed unique responses for each child. The most common changes occurred in the capacity for the hip and knee extensors to produce body support and the hip flexors to produce body propulsion. These results cannot yet be generalized to the broad population of children with CP, but demonstrate that therapy protocols may be enhanced by modeling analyses. The pilot study results provide motivation for gait training emphasizing upright leg posture, mediolateral balance, and ankle push-off.
Elena J. Caruthers, Julie A. Thompson, Ajit M.W. Chaudhari, Laura C. Schmitt, Thomas M. Best, Katherine R. Saul and Robert A. Siston
Sit-to-stand transfer is a common task that is challenging for older adults and others with musculoskeletal impairments. Associated joint torques and muscle activations have been analyzed two-dimensionally, neglecting possible three-dimensional (3D) compensatory movements in those who struggle with sit-to-stand transfer. Furthermore, how muscles accelerate an individual up and off the chair remains unclear; such knowledge could inform rehabilitation strategies. We examined muscle forces, muscleinduced accelerations, and interlimb muscle force differences during sit-to-stand transfer in young, healthy adults. Dynamic simulations were created using a custom 3D musculoskeletal model; static optimization and induced acceleration analysis were used to determine muscle forces and their induced accelerations, respectively. The gluteus maximus generated the largest force (2009.07 ± 277.31 N) and was a main contributor to forward acceleration of the center of mass (COM) (0.62 ± 0.18 m/s2), while the quadriceps opposed it. The soleus was a main contributor to upward (2.56 ± 0.74 m/s2) and forward acceleration of the COM (0.62 ± 0.33 m/s2). Interlimb muscle force differences were observed, demonstrating lower limb symmetry cannot be assumed during this task, even in healthy adults. These findings establish a baseline from which deficits and compensatory strategies in relevant populations (eg, elderly, osteoarthritis) can be identified.