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Daily Myofibrillar Protein Synthesis Rates in Response to Low- and High-Frequency Resistance Exercise Training in Healthy, Young Men

Brandon J. Shad, Janice L. Thompson, James Mckendry, Andrew M. Holwerda, Yasir S. Elhassan, Leigh Breen, Luc J.C. van Loon, and Gareth A. Wallis

exercise, myofibrillar protein synthesis rates remain elevated for approximately 24 hr before returning to basal levels ( Burd et al., 2011 ; Damas et al., 2016 ). Furthermore, a relatively low volume (∼three sets) of resistance exercise appears to maximize postexercise myofibrillar protein synthesis

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Co-Ingestion of Branched-Chain Amino Acids and Carbohydrate Stimulates Myofibrillar Protein Synthesis Following Resistance Exercise in Trained Young Men

Sarah R. Jackman, Gareth A. Wallis, Jinglei Yu, Andrew Philp, Keith Baar, Kevin D. Tipton, and Oliver C. Witard

response of myofibrillar protein synthesis (MyoPS) to the addition of BCAA to CHO ingestion following resistance exercise in trained, young men. Methods Participants and Study Design A total of 11 healthy (body mass [BM]: 86.9 ± 9.5 kg; percent lean mass: 69% ± 5%) resistance-trained (≥two sessions per

Open access

The Effect of Whole Egg Intake on Muscle Mass: Are the Yolk and Its Nutrients Important?

Heitor O. Santos, Gederson K. Gomes, Brad J. Schoenfeld, and Erick P. de Oliveira

. The limited current evidence suggests that egg yolk intake seems to enhance acute increases on myofibrillar protein synthesis, but these effects do not seem to translate into improved muscle mass, at least in young men. That said, this conclusion is based on very limited evidence and more studies are

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Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Healthy Older Men

Andrew M. Holwerda, Jorn Trommelen, Imre W.K. Kouw, Joan M. Senden, Joy P.B. Goessens, Janneau van Kranenburg, Annemie P. Gijsen, Lex B. Verdijk, and Luc J.C. van Loon

ingestion may have a delayed impact (>3 hr) on stimulating muscle connective tissue protein synthesis rates at rest and during postexercise recovery. Our research group has demonstrated that presleep casein protein ingestion and resistance-type exercise increase myofibrillar protein synthesis during

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Making Sense of Muscle Protein Synthesis: A Focus on Muscle Growth During Resistance Training

Oliver C. Witard, Laurent Bannock, and Kevin D. Tipton

.M. ( 2010 ). Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young men . The Journal of Physiology, 588 ( 16 ), 3119 – 3130 . 20581041 Burd , N.A. , West , D.W. , Moore , D

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Age-Related Changes in Skeletal-Muscle Myosin Heavy-Chain Composition: Effect of Mechanical Loading

Ando Pehme, Karin Alev, Priit Kaasik, and Teet Seene

The purpose of this study was to investigate the effect of compensatory hypertrophy (CH), heavy-resistance exercise training (HRET), and simultaneous CH and HRET on fast-twitch skeletal-muscle myofibrillar-protein synthesis, myosin heavy-chain (MHC) turnover rate, and MHC-isoform composition in young and old rats. In young animals all treatments intensified myofibrillar-protein synthesis, whereas in old animals with CH protein synthesis remained unchanged. The relative content of MHC I and IID in plantaris muscle increases with age, and the relative content of MHC IIB decreases. HRET and simultaneous CH and HRET decreased the proportion of MHC IIB and IIA and increased that of MHC IID in young rat muscle. In old rat muscle, relative content of MHC IID decreased and that of MHC IIB increased. CH decreased relative content of MHC IIB in both age groups and of MHC IIA in old animals. Relative content of MHC IID increased in both groups, and of MHC IIA, in young animals. MHC in plantaris of young rats turned over much faster in all types of mechanical loading but in old rats only during HRET and its combination with CH.

Open access

No Difference Between the Effects of Supplementing With Soy Protein Versus Animal Protein on Gains in Muscle Mass and Strength in Response to Resistance Exercise

Mark Messina, Heidi Lynch, Jared M. Dickinson, and Katharine E. Reed

performed correlational analyses between changes in fiber cross-sectional area after 10 weeks of RET and acute measures of myofibrillar protein synthesis. Importantly, myofibrillar protein synthesis was assessed over a 24-hr time course at three time points during the RET: pretraining, at 3 weeks of

Open access

Coingestion of Collagen With Whey Protein Prevents Postexercise Decline in Plasma Glycine Availability in Recreationally Active Men

Thorben Aussieker, Tom A.H. Janssen, Wesley J.H. Hermans, Andrew M. Holwerda, Joan M. Senden, Janneau M.X. van Kranenburg, Joy P.B. Goessens, Tim Snijders, and Luc J.C. van Loon

exercise on myofibrillar protein synthesis lies in conditioning the contractile protein network, the impact on muscle connective protein synthesis lies in improving the connective tissue network responsible for transferring forces generated by the contractile apparatus ( Huijing, 1999 ). Protein ingestion

Open access

Celebrating the Professional Life of Professor Kevin D. Tipton (1961–2022)

Oliver C. Witard, Arny A. Ferrando, and Stuart M. Phillips

.K. , & Phillips , S.M. ( 2014 ). Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: A double-blind, randomized trial . The American Journal of Clinical Nutrition, 99 ( 2 ), 276 – 286 . doi:10.3945/ajcn.113.068775 10.3945/ajcn.113

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The Anabolic Response to Protein Ingestion During Recovery From Exercise Has No Upper Limit in Magnitude and Duration In Vivo in Humans: A Commentary

Oliver C. Witard and Samuel Mettler

. , Phillips , S.M. , Hawley , J.A. , & Coffey , V.G. ( 2013 ). Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis . The Journal of Physiology, 591 ( 9 ), 2319 – 2331 . 10.1113/jphysiol.2012.244897 Churchward