Near-infrared spectroscopy (NIRS) presents an appealing option for investigating hemodynamic changes in the cerebral cortex during exercise. This review examines the physical basis of NIRS and the types of available instruments. Emphasis is placed on the physiological interpretation of NIRS signals. Theories from affective neuroscience and exercise psychobiology, including Davidson's prefrontal asymmetry hypothesis, Dietrich's transient hypofrontality hypothesis, and Ekkekakis's dual-mode model, are reviewed, highlighting the potential for designing NIRS-based tests in the context of exercise. Findings from 28 studies involving acute bouts of exercise are summarized. These studies suggest that the oxygenation of the prefrontal cortex increases during mild-to-moderate exercise and decreases during strenuous exercise, possibly proximally to the respiratory compensation threshold. Future studies designed to test hypotheses informed by psychological theories should help elucidate the significance of these changes for such important concepts as cognition, affect, exertion, and central fatigue.
Gavin Tempest and Gaynor Parfitt
Imagery, as a cognitive strategy, can improve affective responses during moderate-intensity exercise. The effects of imagery at higher intensities of exercise have not been examined. Further, the effect of imagery use and activity in the frontal cortex during exercise is unknown. Using a crossover design (imagery and control), activity of the frontal cortex (reflected by changes in cerebral hemodynamics using near-infrared spectroscopy) and affective responses were measured during exercise at intensities 5% above the ventilatory threshold (VT) and the respiratory compensation point (RCP). Results indicated that imagery use influenced activity of the frontal cortex and was associated with a more positive affective response at intensities above VT, but not RCP to exhaustion (p < .05). These findings provide direct neurophysiological evidence of imagery use and activity in the frontal cortex during exercise at intensities above VT that positively impact affective responses.
Dennis-Peter Born, Thomas Stöggl, Mikael Swarén, and Glenn Björklund
To investigate the cardiorespiratory and metabolic response of trail running and evaluate whether heart rate (HR) adequately reflects the exercise intensity or if the tissue-saturation index (TSI) could provide a more accurate measure during running in hilly terrain.
Seventeen competitive runners (4 women, V̇O2max, 55 ± 6 mL · kg–1 · min–1; 13 men, V̇O2max, 68 ± 6 mL · kg–1 · min–1) performed a time trial on an off-road trail course. The course was made up of 2 laps covering a total distance of 7 km and included 6 steep uphill and downhill sections with an elevation gain of 486 m. All runners were equipped with a portable breath-by-breath gas analyzer, HR belt, global positioning system receiver, and near-infrared spectroscopy (NIRS) device to measure the TSI.
During the trail run, the exercise intensity in the uphill and downhill sections was 94% ± 2% and 91% ± 3% of maximal heart rate, respectively, and 84% ± 8% and 68% ± 7% of V̇O2max, respectively. The oxygen uptake (V̇O2) increased in the uphill sections and decreased in the downhill sections (P < .01). Although HR was unaffected by the altering slope conditions, the TSI was inversely correlated to the changes in V̇O2 (r = –.70, P < .05).
HR was unaffected by the continuously changing exercise intensity; however, TSI reflected the alternations in V̇O2. Recently used exclusively for scientific purposes, this NIRS-based variable may offer a more accurate alternative than HR to monitor running intensity in the future, especially for training and competition in hilly terrain.
Goutham Ganesan, Szu-yun Leu, Albert Cerussi, Bruce Tromberg, Dan M. Cooper, and Pietro Galassetti
Near-infrared spectroscopy has long been used to measure tissue-specific O2 dynamics in exercise, but most published data have used continuous wave devices incapable of quantifying absolute Hemoglobin (Hb) concentrations. We used time-resolved near-infrared spectroscopy to study exercising muscle (Vastus Lateralis, VL) and prefrontal cortex (PFC) Hb oxygenation in 11 young males (15.3 ± 2.1 yrs) performing incremental cycling until exhaustion (peak VO2 = 42.7 ± 6.1 ml/min/kg, mean peak power = 181 ± 38 W). Time-resolved near-infrared spectroscopy measurements of reduced scattering (µs´) and absorption (µa) at three wavelengths (759, 796, and 833 nm) were used to calculate concentrations of oxyHb ([HbO2]), deoxy Hb ([HbR]), total Hb ([THb]), and O2 saturation (stO2). In PFC, significant increases were observed in both [HbO2] and [HbR] during intense exercise. PFC stO2% remained stable until 80% of total exercise time, then dropped (−2.95%, p = .0064). In VL, stO2% decreased until peak time (−6.8%, p = .01). Segmented linear regression identified thresholds for PFC [HbO2], [HbR], VL [THb]. There was a strong correlation between timing of second ventilatory threshold and decline in PFC [HbO2] (r = .84). These findings show that time-resolved near-infrared spectroscopy can be used to study physiological threshold phenomena in children during maximal exercise, providing insight into tissue specific hemodynamics and metabolism.
Y.L. Lo, H.H. Zhang, C.C. Wang, Z.Y. Chin, S. Fook-Chong, C. Gabriel, and C.T. Guan
In overt reading and singing tasks, actual vocalization of words in a rhythmic fashion is performed. During execution of these tasks, the role of underlying vascular processes in relation to cortical excitability changes in a spatial manner is uncertain. Our objective was to investigate cortical excitability changes during reading and singing with transcranial magnetic stimulation (TMS), as well as vascular changes with nearinfrared spectroscopy (NIRS). Findings with TMS and NIRS were correlated. TMS and NIRS recordings were performed in 5 normal subjects while they performed reading and singing tasks separately. TMS was applied over the left motor cortex at 9 positions 2.5 cm apart. NIRS recordings were made over these identical positions. Although both TMS and NIRS showed significant mean cortical excitability and hemodynamic changes from baseline during vocalization tasks, there was no significant spatial correlation of these changes evaluated with the 2 techniques over the left motor cortex. Our findings suggest that increased left-sided cortical excitability from overt vocalization tasks in the corresponding “hand area” were the result of “functional connectivity,” rather than an underlying “vascular overflow mechanism” from the adjacent speech processing or face/mouth areas. Our findings also imply that functional neurophysiological and vascular methods may evaluate separate underlying processes, although subjects performed identical vocalization tasks. Future research combining similar methodologies should embrace this aspect and harness their separate capabilities.
Pai-Yun Cheng, Hsiao-Feng Chieh, Chien-Ju Lin, Hsiu-Yun Hsu, Jia-Jin J. Chen, Li-Chieh Kuo, and Fong-Chin Su
volume, and oxygenation of the brains of older adults has recently attracted the attention of researchers. The neuron activation and hemodynamic responses in the cerebral cortex are closely coupled. Near-infrared spectroscopy (NIRS) is a noninvasive, low cost, and low-space requirement technique that can
Luca Pollonini, Lauren Gulley Cox, and Stacey L. Gorniak
size was increased until the subject was able to detect its touch a minimum of two times at the same location. Muscle Hemodynamics Measurements To measure hemodynamic function, we used a near-infrared spectroscopy (NIRS) sensor, measuring concentrations of HbO and HbR of the flexor digitorum
Satoshi Matsuno, Takuya Yoshiike, Atsushi Yoshimura, Sachiyo Morita, Yusuke Fujii, Motoyasu Honma, Yuji Ozeki, and Kenichi Kuriyama
activity in the PAA would be associated with an improvement in standing postural stability associated with SPPT. To test this hypothesis, we evaluated two-point discrimination of plantar skin and cortical activity measured by near-infrared spectroscopy (NIRS) during SPPT and correlated these measures with
Daisuke Kume, Akira Iguchi, and Hiroshi Endoh
Near-infrared spectroscopy (NIRS) is a useful technique for assessing noninvasive muscle oxygenation profiles during exercise ( 6 , 14 ). Specifically, NIRS measures the concentration changes in oxygenated and deoxygenated hemoglobin and myoglobin (ΔOxy-Hb and ΔDeoxy-Hb, respectively). It is known
Erin Calaine Inglis, Danilo Iannetta, Daniel A. Keir, and Juan M. Murias
” is a key element in predicting performance and assessing training effectiveness. 1 Among the indices thought to reflect this important boundary are the respiratory compensation point (RCP) and the near-infrared spectroscopy-derived muscle deoxyhemoglobin ([HHb]) break point ([HHb] BP ) of ramp