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Acute Exercise, Plasma Nitric Oxide, and Blood Pressure in Older Adults With Different Levels of Training Status: The Influence of Polymorphisms of Endothelial Nitric Oxide Synthase

Thaís Amanda Reia, Roberta Fernanda da Silva, André Mourão Jacomini, Ana Maria Guilmo Moreno, Letícia Perticarra Ferezin, Sherliane Carla Pereira, Riccardo Lacchini, Thiago José Dionísio, Carlos Ferreira Santos, and Anderson Saranz Zago

Hypertension (HT) has stood out as the most prevalent disease in the older adult population. In addition, genetic variation has been associated with a high influence on the development of HT; thus, some polymorphisms of endothelial nitric oxide synthase gene (eNOS) are studied as an important

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Skin Blood Flow Responses to Acetylcholine, Local Heating, and to 60% VO2max exercise with and without Nitric Oxide inhibition, in Boys vs. Girls

Raffaele Joseph Massarotto, Gary J. Hodges, Alexandra Woloschuk, Deborah D. O’Leary, Raffy Dotan, and Bareket Falk

vasodilation during exercise-induced heat stress. Local ACh delivery (eg, via iontophoresis) also results in stimulation of cutaneous endothelium leading to vasodilation, which is partly mediated by nitric oxide (NO) along with prostaglandins and endothelial hyperpolarizing factors ( 6 , 10 ). Recent studies

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Beneficial Impact of Moderate to Vigorous Physical Activity Program on Circulating Number and Functional Capacity of Endothelial Progenitor Cells in Children: The Crucial Role of Nitric Oxide and VEGF-A

Livia Victorino Souza, Franciele De Meneck, Vanessa Oliveira, Elisa Mieko Higa, Eliana Hiromi Akamine, and Maria do Carmo Franco

not entirely clear but have been linked to an increase in vascular endothelial growth factor (VEGF), nitric oxide (NO) bioavailability, hypoxic-inducible factor 1, and matrix metalloproteinase 9 ( 19 , 21 , 36 ). It is important to note that the release of EPCs in response to physical activity occurs

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Effect of Wrestling Exercise on Oxidative DNA Damage, Nitric Oxide Level and Paraoxonase Activity in Adolescent Boys

Zuhal Hamurcu, Nazmi Saritas, Gulden Baskol, and Nese Akpinar

The objective of the current study is to determine the effects of regular wrestling exercise oxidative DNA damage and antioxidant parameters. The findings of the current study have shown that 8-hydroxy-2’-deoxyguanosine (8-OHdG) obtained from wrestlers in basal status were significantly lower than those of sedentary (p = .001). In contrast, Nitric oxide (NO) and Paraoxonase-1 (PON1) were remarkably higher in wrestlers in basal status than those of sedentary (respectively, p = .001, p = .024). While the NO of wrestlers increased immediately after a 1.5-h exercise compared with those before exercise (p = .002), no differences was found between before and immediately after a 1.5-h exercise in 8-OHdG and PON1 (respectively, p = .777, p = .408).Statistically significant correlations were found between the NO and PON1 in the wrestlers in basal status (r = .671, p = .002). In conclusion, our study suggests that wrestling exercise for a healthy life is important in that it reduces DNA damage as well as enhancing antioxidant parameters.

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Effects of 7 Days of Arginine-Alpha-Ketoglutarate Supplementation on Blood Flow, Plasma L-Arginine, Nitric Oxide Metabolites, and Asymmetric Dimethyl Arginine After Resistance Exercise

Darryn S. Willoughby, Tony Boucher, Jeremy Reid, Garson Skelton, and Mandy Clark


Arginine-alpha-ketoglutarate (AAKG) supplements are alleged to increase nitric oxide production, thereby resulting in vasodilation during resistance exercise. This study sought to determine the effects of AAKG supplementation on hemodynamics and brachial-artery blood flow and the circulating levels of L-arginine, nitric oxide metabolites (NOx; nitrate/nitrite), asymmetric dimethyl arginine (ADMA), and L-arginine:ADMA ratio after resistance exercise.


Twenty-four physically active men underwent 7 days of AAKG supplementation with 12 g/day of either NO2 Platinum or placebo (PLC). Before and after supplementation, a resistance-exercise session involving the elbow flexors was performed involving 3 sets of 15 repetitions with 70–75% of 1-repetition maximum. Data were collected immediately before, immediately after (PST), and 30 min after (30PST) each exercise session. Data were analyzed with factorial ANOVA (p < .05).


Heart rate, blood pressure, and blood flow were increased in both groups at PST (p = .001) but not different between groups. Plasma L-arginine was increased in the NO2 group (p = .001). NOx was shown to increase in both groups at PST (p = .001) and at 30PST (p = .001) but was not different between groups. ADMA was not affected between tests (p = .26) or time points (p = .31); however, the L-arginine:ADMA ratio was increased in the NO2 group (p = .03).


NO2 Platinum increased plasma L-arginine levels; however, the effects observed in hemodynamics, brachial-artery blood flow, and NOx can only be attributed to the resistance exercise.

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Multiday Pomegranate Extract Supplementation Decreases Oxygen Uptake During Submaximal Cycling Exercise, but Cosupplementation With N-acetylcysteine Negates the Effect

Emma M. Crum, Matthew J. Barnes, and Stephen R. Stannard

accompanied by increased postexercise blood flow. The results of this study linked findings from previous investigations involving beetroot juice (BRJ). Both POMx and BRJ contain significant concentrations of nitrates (NO 3 − ), a precursor to the powerful vasodilator and signaling compound, nitric oxide (NO

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Multicomponent Training Changes Blood Pressure and Redox Status in Older Women: Influence of β2 Adrenergic Receptor Haplotypes

Thiago Correa Porto Gonçalves, Atila Alexandre Trapé, Jhennyfer Aline Lima Rodrigues, Simone Sakagute Tavares, and Carlos Roberto Bueno Junior

can be considered one of the main modifiable factors (environment) to mitigate the deleterious impact of the aging process ( Neves et al., 2016 ). It is known that exercise training is associated with the increase in nitric oxide (NO), an important vasodilator and homeostatic agent interacting with

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What Is in Your Beet Juice? Nitrate and Nitrite Content of Beet Juice Products Marketed to Athletes

Edgar J. Gallardo and Andrew R. Coggan

Numerous studies in recent years have investigated the effects of dietary nitrate (NO 3 − ) on the physiological responses to, and/or performance during, exercise. This interest stems from the fact that dietary NO 3 − is an important source of nitric oxide (NO) via the “reverse” NO 3 −  → nitrite

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Effect of Dark Chocolate Supplementation on Tissue Oxygenation, Metabolism, and Performance in Trained Cyclists at Altitude

Keely Shaw, Jyotpal Singh, Luke Sirant, J. Patrick Neary, and Philip D. Chilibeck

plasma nitric oxide (NO). Domínguez et al. ( 2017 ) reviewed the effects of beetroot juice on endurance exercise performance and concluded that chronic supplementation with beetroot juice may lead to a decreased oxygen consumption (VO 2 ) at an intensity of 70% VO 2 max, improved time to exhaustion, and

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Dietary Nitrate Supplementation Improves Rowing Performance in Well-Trained Rowers

Hannah Bond, Lillian Morton, and Andrea J. Braakhuis

Increased plasma nitrate concentrations from dietary sources of nitrate have proven to benefit exercise performance. Beetroot (BR) contains relatively high levels of nitrate (NO3 ), which increases nitric oxide stores. This study investigated whether dietary nitrate supplementation, in the form of a BR beverage, would improve rowing performance during ergometer repetitions. In a randomized crossover design, 14 well-trained junior male rowers consumed 500 ml of either BR or placebo (PL) daily for 6 d. After supplementation, rowers completed 6 maximal 500-m ergometer repetitions and times were recorded. A 7-d washout period separated the 2 trials. Blood pressure, oxygen saturation, maximum heart rate, urine (specific gravity, pH, and nitrites), and lactates were collected for analysis at baseline and pre- and postperformance. Changes in the mean with 95% confidence limits were calculated. There was a likely benefit to average repetition time in the BR condition, compared with PL (0.4%, 95% confidence limits, ± 1.0%). In particular, Repetitions 4–6 showed an almost certain benefit in rowing time on BR (1.7%, 95% CL, ± 1.0%). The underlying mechanism for the observed results remains unknown, as differences observed in rowers’ physiological measures between the 2 conditions were unclear. Conclusively, nitrate supplementation in the form of BR juice resulted in improved maximal rowing-ergometer repetitions, particularly in the later stages of exercise.