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Gustavo Monnerat, Alex S. Maior, Marcio Tannure, Lia K.F.C. Back and Caleb G.M. Santos

genomic databases may contribute for precision medicine, personalized training, sports medicine, and sports performance. In addition, those results may suggest certain trends among populations, allowing a better understanding of interindividual aspects related to sports performance. Training strategies

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Kathleen F. Janz

Of all the lifestyle strategies for increasing bone strength during the growing years, physical activity is one of the most efficacious. This commentary highlights two exceptional 2016 publications addressing bone strength in children and adolescents with an eye toward reduced fracture risk later in life. The first by Weaver et al. was selected due to its comprehensive approach to understanding bone development. The second by Mitchell et al explores a new field of inquiry, that is, genetic-environment interaction as represented by bone mineral density-lowering alleles and high-impact physical activity. It is a first look at future precision medicine as it may pertain to pediatric bone strength.

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Patty Freedson

et al., 2017 ; “Fitbit Selected for National Institutes of Health (NIH) Precision Medicine Research Program with The Scripps Research Institute (TSRI),” 2017 ; Wang et al., 2015 ) has the potential to increasingly limit cross-study comparability of behavioral outcomes. Such validation studies

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David R. Bassett, Patty S. Freedson and Dinesh John

toward evidence-based behavioral goals, could be a powerful adjunctive therapy in the treatment of chronic diseases. NIH and the “All of Us” Program: A New Research Frontier In 2016, NIH launched the Precision Medicine Initiative with the goal of bringing precision medicine to all areas of health and

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Catrine Tudor-Locke and Elroy J. Aguiar

opportunities associated with step-based physical activity metrics and contemporary wearable technologies, we also consider some additional areas of discussion, such as zero cadence as a proxy of sedentary time, the accuracy of wearable technology, and precision medicine. We focus herein on the potential for

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Alex V. Rowlands, Tatiana Plekhanova, Tom Yates, Evgeny M. Mirkes, Melanie Davies, Kamlesh Khunti and Charlotte L. Edwardson

statistical power to investigate precise dose-response associations between physical activity and health; and the investigation of multi-level determinants of physical activity within and across populations. Addressing these issues could provide the foundation for precision medicine approaches to targeted and

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Dan M. Cooper

 al . Integration of molecular pathology, epidemiology and social science for global precision medicine . Expert Rev Mol Diagn . 2016 ; 16 : 11 – 23 . PubMed ID: 26636627 doi:10.1586/14737159.2016.1115346 10.1586/14737159.2016.1115346 26636627 75. Ostrowski K , Rohde T , Asp S , Schjerling P