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The Relationship between Bone Adaptations to Resistance Exercise and Reproductive-Hormone Levels

Steven A. Hawkins, Robert A. Wiswell, and E. Todd Schroeder

This study examined the relationships between high-intensity resistance exercise and bone mass in postmenopausal women and serum reproductive-hormone levels and bone-mass changes in response to resistance exercise. Women 45–65 years old were assigned to an exercise or a control group. They trained 3 times weekly for 18 weeks at 90,70, and 80% of their 1-RM. Groups were not different in age, height, body mass, muscle strength, or lean body mass. Initial muscle strength increased significantly in the training group. Total hip and intertrochanter bone-mineral density (BMD) increased in the training group. Estradiol, testosterone, osteocalcin, and CrossLaps concentration did not change in either group. Serum estradiol was significantly related to change in BMD at the hip, femoral neck, and intertrochanter, as well as change in lean mass. Results suggest that high-intensity resistance exercise can increase BMD of the hip and that serum estrogen concentrations might influence bone and muscle adaptations to resistance exercise in postmenopausal women.

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Low Energy Availability Is Difficult to Assess but Outcomes Have Large Impact on Bone Injury Rates in Elite Distance Athletes

Ida A. Heikura, Arja L.T. Uusitalo, Trent Stellingwerff, Dan Bergland, Antti A. Mero, and Louise M. Burke

-class distance female and male athletes with two primary purposes: (a) to provide a cross-sectional report on measurements of EA, metabolic and reproductive hormonal function, bone mineral density (BMD), injury/illness rates, and body composition during a high-volume/intensity precompetition training period and

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Female Physiology–Endocrinology: Education Is Lacking and Innovation Is Needed!

Anthony C. Hackney and Kirsty J. Elliott-Sale

more rarely developed fully as a curricular topic. As a result, there is a lack of female endocrinology knowledge in exercise–sports scientists, and as such they are challenged to the ever-changing reproductive hormonal landscape in women in their research. Put simply, there are generations of

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The Utility of the Low Energy Availability in Females Questionnaire to Detect Markers Consistent With Low Energy Availability-Related Conditions in a Mixed-Sport Cohort

Margot A. Rogers, Michael K. Drew, Renee Appaneal, Greg Lovell, Bronwen Lundy, David Hughes, Nicole Vlahovich, Gordon Waddington, and Louise M. Burke

progesterone concentrations were analyzed by an external laboratory (Laverty Pathology, Macquarie Park, NSW, Australia) from fasted venous blood samples. Participants who reported the use of hormonal contraceptives were not assessed for reproductive hormone concentrations. Additional biomarkers were assessed

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Diet and Weight Changes of Female Bodybuilders Before and After Competition

Janet Walberg-Rankin, Cynthia Eckstein Edmonds, and Frank C. Gwazdauskas

This study assessed nutritional and body weight patterns in 6 female body- builders approximately a month before and after a competition. The women kept dietary and body weight records and two of them also agreed to collect morning urine samples to provide information about their menstrual cycle. All women lost weight before and gained weight after competition. Energy intake was modestly restricted and the subjects consumed a moderate-protein, low-fat, high-carbohydrate diet just prior to competition. Energy intake doubled, and total grams of fat increased approximately tenfold just after competition. Urinary data indicated that the cycle following competition was prolonged, with reduced reproductive hormone concentrations. In summary, the women practiced extreme dietary control while preparing for a competi- tion but followed the event with a higher energy and fat intake. These changes in diet and body weight may contribute to the disturbances previously observed in the menstrual cycle of these athletes.

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Athletic Performance and the Oral Contraceptive

Claire Rechichi, Brian Dawson, and Carmel Goodman

Some reports suggest variation in physiological responses and athletic performance, for female athletes at specific phases of the menstrual cycle. However, inconsistent findings are common due to the inappropriate verification of menstrual cycle phase, small subject numbers, high intra- and interindividual variability in estrogen and progesterone concentration, and the pulsatile secretion of these hormones. Therefore, the oral contraceptive (OC) cycle may provide a more stable environment in which to evaluate the acute effect of reproductive hormones on physiological variables and exercise performance. To date, most of the OC research has compared differences between OC use and nonuse, and few researchers have examined within-cycle effects of the OC. It is also apparent that OC use is becoming far more prevalent in athletes; hence the effect of the different exogenous and endogenous hormonal profiles on athletic performance should be investigated. Research to date identifies potential for variation in aerobic performance, anaerobic capacity, anaerobic power and reactive strength throughout an OC cycle. The purpose of this review is to present and evaluate the current literature on the physiology of exercise and athletic performance during the OC cycle.

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Alternate-Day Low Energy Availability During Spring Classics in Professional Cyclists

Ida A. Heikura, Marc Quod, Nicki Strobel, Roger Palfreeman, Rita Civil, and Louise M. Burke

Purpose: To assess energy and carbohydrate (CHO) availability and changes in blood hormones in 6 professional male cyclists over multiple single-day races. Methods: The authors collected weighed-food records, power-meter data, and morning body mass measurements across 8 d. CHO intakes were compared with contemporary guidelines. Energy availability (EA) was calculated as energy intake minus exercise energy expenditure, relative to fat-free mass (FFM). Skinfold thickness and blood metabolic and reproductive hormones were measured prestudy and poststudy. Statistical significance was defined as P ≤ .05. Results: Body mass (P = .11) or skinfold thickness (P = .75) did not change across time, despite alternate-day low EA (14 [9] vs 57 [10] kcal·kg−1 FFM·d−1, race vs rest days, respectively; P < .001). Cyclists with extremely low EA on race days (<10 kcal·kg−1 FFM·d−1; n = 2) experienced a trend toward decreased testosterone (−14%) and insulin-like growth factor 1 (−25%), despite being high EA (>46 kcal·kg−1 FFM·d−1) on days between. CHO intakes were significantly higher on race versus rest days (10.7 [1.3] vs 6.4 [0.8] g·kg−1·d−1, respectively; P < .001). The cyclists reached contemporary prerace fueling targets (3.4 [0.7] g·kg−1·3 h−1 CHO; P = .24), while the execution of CHO guidelines during race (51 [9] g·h−1; P = .048) and within acute (1.6 [0.5] g·kg−1·3 h−1; P = .002) and prolonged (7.4 [1.0] g·kg−1·24 h−1; P = .002) postrace recovery was poor. Conclusions: The authors are the first to report the day-by-day periodization of energy and CHO in a small sample of professional cyclists. They also examined the logistics of conducting a field study under stressful conditions in which major cooperation from the subjects and team management is needed. Their commentary around these challenges and possible solutions is a major novelty of the article.

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“Invisible Sportswomen 2.0”—Digging Deeper Into Gender Bias in Sport and Exercise Science Research: Author Gender, Editorial Board Gender, and Research Quality

Emma S. Cowley, Sam R. Moore, Alyssa A. Olenick, and Kelly L. McNulty

unwillingness to assess and/or control for female-specific considerations, such as reproductive hormonal milieu, has resulted in most research in this area being of low quality ( Elliott-Sale et al., 2021 ). While there is no shortage of methodological papers to assist researchers in including women as

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The Symptoms Experienced by Naturally Menstruating Women and Oral Contraceptive Pill Users and Their Perceived Effects on Exercise Performance and Recovery Time Posttraining

Kelly L. McNulty, Paul Ansdell, Stuart Goodall, Kevin Thomas, Kirsty J. Elliott-Sale, Glyn Howatson, and Kirsty M. Hicks

, given that sportswomen (irrespective of reproductive hormonal profile) might be affected by cycle-related symptoms, and that these symptoms have the potential to influence aspects of exercise performance and training, it is important to gain a better understanding of symptoms in this population

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Vagally Derived Heart Rate Variability and Training Perturbations With Menses in Female Collegiate Rowers

Sara R. Sherman, Clifton J. Holmes, Alexander P. Demos, Tori Stone, Bjoern Hornikel, Hayley V. MacDonald, Michael V. Fedewa, and Michael R. Esco

has established a connection between HRV and fatigue accumulated from training, a majority of these studies did not include female athletes, nor investigate potential female-specific RMSSD responses. Female reproductive hormones, such as estrogen and progesterone, are introduced in a cyclic