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Panagiota Klentrou, Kirina Angrish, Nafisa Awadia, Nigel Kurgan, Rozalia Kouvelioti and Bareket Falk

mechanical strain to bones by applying ground reaction forces, thereby activating osteocytes, which are mechanosensitive cells ( 18 ). Sclerostin is one of the key molecules produced by osteocytes to regulate the bone’s response to mechanical loading and unloading ( 36 , 38 ). In fact, sclerostin levels

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Jennifer Dekker, Katlynne Nelson, Nigel Kurgan, Bareket Falk, Andrea Josse and Panagiota Klentrou

formation ( 18 ). Sclerostin (SOST) and dickkopf-1 (DKK-1) are catabolic osteokines that inhibit the Wnt glycoproteins from attaching to the LRP5/6 receptor complex ( 30 , 38 ), thus leading to inhibition of bone formation. In addition, uninhibited Wnt signaling is an important regulator of the production