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Jean M. Nyakayiru, Kristin L. Jonvik, Philippe J.M. Pinckaers, Joan Senden, Luc J.C. van Loon and Lex B. Verdijk

While the majority of studies reporting ergogenic effects of dietary nitrate have used a multiday supplementation protocol, some studies suggest that a single dose of dietary nitrate before exercise can also improve subsequent performance. We aimed to compare the impact of acute and 6-day sodium nitrate supplementation on oxygen uptake (V̇O2) and time-trial performance in trained cyclists. Using a randomized, double-blind, cross-over design, 17 male cyclists (25 ± 4 y, V̇O2peak 65 ± 4 ml·kg-1·min-1, Wmax 411 ± 35 W) were subjected to 3 different trials; 5 days placebo and 1 day sodium nitrate supplementation (1-DAY); 6 days sodium nitrate supplementation (6-DAY); 6 days placebo supplementation (PLA). Nitrate was administered as 1097 mg sodium nitrate providing 800 mg (~12.9 mmol) nitrate per day. Three hours after ingestion of the last supplemental bolus, indirect calorimetry was performed while subjects performed 30 min of exercise at 45% Wmax and 30 min at 65% Wmax on a cycle ergometer, followed by a 10 km time-trial. Immediately before exercise, plasma [nitrate] and [nitrite] increased to a similar extent during the 6-DAY and 1-DAY trial, but not with PLA (plasma nitrite: 501 ± 205, 553 ± 278, and 239 ± 74 nM, respectively; p < .001). No differences were observed between interventions in V̇O2 during submaximal exercise, or in time to complete the time-trial (6-DAY: 1004 ± 61, 1-DAY: 1022 ± 72, PLA: 1017 ± 71 s; p = .28). We conclude that both acute and 6-days of sodium nitrate supplementation do not alter V̇O2 during submaximal exercise or improve time-trial performance in highly trained cyclists, despite increasing plasma [nitrate] and [nitrite].

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Matthew W. Hoon, Nathan A. Johnson, Phillip G. Chapman and Louise M. Burke

The purpose of this review was to examine the effect of nitrate supplementation on exercise performance by systematic review and meta-analysis of controlled human studies. A search of four electronic databases and cross-referencing found 17 studies investigating the effect of inorganic nitrate supplementation on exercise performance that met the inclusion criteria. Beetroot juice and sodium nitrate were the most common supplements, with doses ranging from 300 to 600 mg nitrate and prescribed in a manner ranging from a single bolus to 15 days of regular ingestion. Pooled analysis showed a significant moderate benefit (ES = 0.79, 95% CI: 0.23–1.35) of nitrate supplementation on performance for time to exhaustion tests (p = .006). There was a small but insignificant beneficial effect on performance for time trials (ES = 0.11, 95% CI: –0.16–0.37) and graded exercise tests (ES = 0.26, 95% CI: –0.10–0.62). Qualitative analysis suggested that performance benefits are more often observed in inactive to recreationally active individuals and when a chronic loading of nitrate over several days is undertaken. Overall, these results suggest that nitrate supplementation is associated with a moderate improvement in constant load time to exhaustion tasks. Despite not reaching statistical significance, the small positive effect on time trial or graded exercise performance may be meaningful in an elite sport context. More data are required to clarify the effect of nitrate supplementation on exercise performance and to elucidate the optimal way to implement supplementation.

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Edgar J. Gallardo and Andrew R. Coggan

.1152/japplphysiol.00046.2010 10.1152/japplphysiol.00046.2010 Bescós , R. , Feerrer-Roca , V. , Galilea , P.A. , Roig , A. , Drobnic , F. , Sureda , A. , … Pons , A. ( 2012 ). Sodium nitrate supplementation does not enhance endurance performance of endurance athletes . Medicine & Science in Sports

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Blair Crewther, Konrad Witek, Paweł Draga, Piotr Zmijewski and Zbigniew Obmiński

.M. ( 2015 ). Influence of a D-aspartic acid/sodium nitrate/vitamin D3 dietary supplement on physiological parameters in middle-aged men: A pilot study . The Open Nutraceuticals Journal, 8 , 43 – 48 . doi:10.2174/1876396001508010043 10.2174/1876396001508010043 D’Aniello , A. ( 2007 ). D-Aspartic acid