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Marcus Colon, Andrew Hodgson, Eimear Donlon, and James E.J. Murphy

, & Greider, 1990 ), and loss of telomere length (TL) provides a measure of replicative senescence ( Benetos et al., 2001 ). Telomeres act as a mitotic clock and have even been proposed as a marker of biological aging ( Butler et al., 2004 ). Telomere-related senescence has been linked to age

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Carlos A. Muniesa, Zoraida Verde, Germán Diaz-Ureña, Catalina Santiago, Fernando Gutiérrez, Enrique Díaz, Félix Gómez-Gallego, Helios Pareja-Galeano, Luisa Soares-Miranda, and Alejandro Lucia

Growing evidence suggests that regular moderate-intensity physical activity is associated with an attenuation of leukocyte telomere length (LTL) shortening. However, more controversy exists regarding higher exercise loads such as those imposed by elite-sport participation.

Methods:

The authors investigated LTL differences between young elite athletes (n = 61, 54% men, age [mean ± SD] 27.2 ± 4.9 y) and healthy nonsmoker, physically inactive controls (n = 64, 52% men, 28.9 ± 6.3 y) using analysis of variance (ANOVA).

Results:

Elite athletes had, on average, higher LTL than control subjects, 0.89 ± 0.26 vs 0.78 ± 0.31, P = .013 for the group effect, with no significant sex (P = .995) or age effect (P = .114).

Conclusions:

The results suggest that young elite athletes have longer telomeres than their inactive peers. Further research might assess the LTL of elite athletes of varying ages compared with both age-matched active and inactive individuals.

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Matt Nickels, Sarabjit Mastana, Veryan Codd, Matthew Denniff, and Elizabeth Akam

influence telomere dynamics ( Dimauro et al., 2016 ; Krishna et al., 2015 ; Werner et al., 2018 ). To date, most studies exploring the relationship between telomere length (TL) and exercise are centered on self-reported physical activity ( Dankel et al., 2017 ; Krauss et al., 2011 ; Latifovic et

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Paul D. Loprinzi and Jeremy P. Loenneke

Objective:

Leukocyte telomere length (LTL) shortening is characteristic of aging and is associated with morbidity and mortality, independent of age. Research demonstrates that lower extremity muscular strength is associated with mobility, morbidity and mortality; however, no study, to our knowledge, had examined the association between lower extremity muscular strength and LTL, which was the purpose of this brief study.

Methods:

Data from the 1999–2002 NHANES was used (N = 2410; 50–85 years). Peak isokinetic knee extensor strength (IKES) was objectively measured with LTL assessed from a blood sample.

Results:

After adjustments, for every 50 N increase in IKES, participants had a 9% reduced odds (P = .04) of being in the 1st (vs. 4th) LTL quartile.

Discussion:

Lower extremity muscular strength is associated with LTL, suggesting a possible mechanism through which lower extremity muscular strength may be associated with morbidity and mortality.

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Gislaine S. Kogure, Cristiana L. Miranda-Furtado, Daiana C.C. Pedroso, Victor B. Ribeiro, Matheus C. Eiras, Rafael C. Silva, Lisandra C. Caetano, Rui A. Ferriani, Rodrigo T. Calado, and Rosana M. dos Reis

associated with obesity and IR. 9 A shorter telomere length has been associated with higher general and abdominal adiposity 10 and lower lean body mass, 11 particularly in women. 12 There is evidence that physical exercise can influence telomere and telomerase activity and could influence the regulation

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Stephen M. Roth

Physical activity has long been touted as a means of reducing susceptibility to age-related disease and multiple studies have shown reduced mortality rates in individuals with a lifestyle including regular exercise. A variety of mechanisms for how physical activity reduces age-related diseases have been explored and multiple, redundant explanatory mechanisms are likely to emerge. Evidence has emerged that physical activity may impact directly on telomere biology, one of the primary theories of cellular aging. Telomeres are located at the ends of chromosomes and as cells divide, incomplete DNA replication results in telomere shortening; once shortening reaches a critical threshold, cell senescence results. Investigators hypothesize that part of the favorable influence of physical activity on mortality rates and age-related disease occurs through a direct impact on telomere biology, including delaying rates of telomere shortening. The present review examines key recent findings in this area and explores some of the unanswered questions and future directions for the field.

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Scott J. Dankel, Jeremy P. Loenneke, and Paul D. Loprinzi

-specific mortality. This is of importance given the association between muscle strength and various health-related markers (eg, diabetes prevalence and severity, 4 leukocyte telomere length 5 ), which may help to reduce the prevalence of cancer-specific mortality. 6 Prospective studies on the effects of lower

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Meghan K. Edwards and Paul D. Loprinzi

beneficial effects of muscular strength improvements have also been shown to extend to adults with human immunodeficiency virus 23 and Parkinson’s disease. 24 Of additional note, recent work demonstrates a direct association between lower extremity muscle strength and leukocyte telomere length, with

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Caio Victor Sousa, Beat Knechtle, and Pantelis Theo Nikolaidis

: how to grow old healthy . Exerc Sport Sci Rev . 2015 ; 43 ( 1 ): 57 – 64 . PubMed ID: 25390294 doi:10.1249/JES.0000000000000033 10.1249/JES.0000000000000033 25390294 21. Sousa CV , Aguiar SS , Santos PA , et al . Telomere length and redox balance in master endurance runners: the role of

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Giovanni Mario Pes, Maria Pina Dore, Alessandra Errigo, and Michel Poulain

, 1518 – 1524 . PubMed doi:10.1093/gerona/glt054 10.1093/gerona/glt054 Cherkas , L.F. , Hunkin , J.L. , Kato , B.S. , Richards , J.B. , Gardner , J.P. , Surdulescu , G.L. , … Aviv , A. ( 2008 ). The association between physical activity in leisure time and leukocyte telomere length