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The purpose of this investigation was to examine the effects of preceding oral creatine monohydrate with a lacto-ovo-vegetarian diet on muscle creatine concentration. Thirty-two healthy men, who regularly consumed an omnivorous diet, were randomly assigned to consume a weight maintaining, lacto-ovo-vegetarian (LOV; n = 16) or omnivorous (Omni; n = 16) diet for 26 days. In addition to their assigned diet, on day 22 of the study, subjects were assigned in a double-blind manner to receive either creatine monohydrate (CM; 0.3 g · kg · d−1 + 20 g Polycose) or an equivalent dose of placebo (PL) for 5 days. There were no significant differences between the LOV and Omni groups at baseline with respect to age, height, and weight. The results demonstrated that consuming a LOV diet for 21 days was an effective procedure to decrease muscle creatine concentration (p < .01) in individuals who normally consume meat and fish in their diet. However, muscle total creatine (TCr) following creatine supplementation did not differ statistically between LOV and Omni diet groups (148.6 ± 4.5 vs. 141.7 ± 4.5 mmol · kg−1 d.m.).

J.M. Lukaszuk is with the Department of Nutrition Dietetics and Hospitality Administration at Northern Illinois University, DeKalb, IL 60115. R.J. Robertson is with the Center of Exercise and Health Fitness Research at the University of Pittsburgh, Pittsburgh, PA 15261. J.E. Arch is with the General Clinical Research Center, G.E. Moore is with Preventive Cardiology, K.M. Yaw is with Orthopedics, D.E. Kelley is with Endocrinology and Metabolism, and J.T. Rubin is with Surgical Oncology—all at the University of Pittsburgh School of Medicine, Pittsburgh, PA 15213. N.M. Moyna is with the Center for Sport Science and Health at Dublin City University, Dublin 9, Ireland.