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Androgen-deprivation therapy (ADT) for prostate cancer (PCa) has side effects that significantly impair health-related quality of life (HRQOL). Exercise ameliorates many side effects of ADT, but different modalities, particularly in the home-based setting, have not been well studied. In this study the authors randomly assigned 66 PCa survivors receiving ADT to 6 mo of home-based aerobic or resistance training. Psychosocial well-being and physical fitness were measured at baseline, 3 and 6 mo, and then 6 mo postintervention. Intention-to-treat analyses showed that fatigue and HRQOL were not significantly different between groups; however, in a per-protocol analysis the resistance-exercise training group demonstrated clinically significant improvements in HRQOL. Differential within-group effects on physical fitness were also observed at various time points. At all time points, the aerobic-training group engaged in significantly more physical activity than the resistance-training group, a finding that should be further examined given evidence-based guidelines for activity volume in cancer survivors.

Santa Mina is with the Kinesiology Program, University of Guelph-Humber, Toronto, ON, Canada. Alibhai is with the Div. of General Internal Medicine and Geriatrics, University Health Network, Toronto, ON, Canada. Matthew and Trachtenberg are with the Dept. of Surgical Oncology, Div. of Urology, Princess Margaret Cancer Centre, Toronto, ON, Canada. Guglietti, Pirbaglou, and Ritvo are with the School of Kinesiology and Health Science, York University, Toronto, ON, Canada.