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Background:

Highly active antiretroviral therapy (HAART) is associated with high total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), triglyceride (TG), and C-reactive protein (CRP) levels. The natural course of the HIV infection reduces the high-density lipoprotein level (HDL-c). Thus, physical exercise plays a key role in reducing the effects of HAART and HIV.

Methods:

Thirty people living with HIV (PLHIV) were randomized to the nonlinear resistance training (NLRT) and control (CON) groups. The NLRT group underwent 12 weeks of resistance training, whereas the CON group maintained usual daily activities. All volunteers underwent anthropometric, body composition, and biochemical assessments at the beginning and end of 12 weeks.

Results:

After 12 weeks, the NLRT group had increased lean body mass (P < .0001), and a reduction in body fat mass (P < .0001) and body fat percentage (P < .0001). The levels of TC (P < .0001), LDL-c (P = .049), TG (P < .0001), and CRP (P = .004) were reduced, and the HDL-c level increased (P < .0001).

Conclusion

Twelve weeks of NLRT causes beneficial changes in the body composition, lipid profile, and inflammation markers in PLHIV, and it can be used in this patient population.

Zanetti (hugo.zanetti@hotmail.com), da Cruz, Lourenço, and Mendes are with the Post-Graduate Program in Physical Education, Federal University of Triângulo Mineiro, Uberaba/MG, Brazil. Ribeiro is with the Medical Clinical Program, Beneficência Portuguesa de São Paulo Hospital, São Paulo/SP, Brazil. Ferreira de Jesus Leite is with the Sports Science Department, Federal University of Triângulo Mineiro, Uberaba/MG, Brazil. Neves and Silva-Vergara are with the Post-Graduate Program in Tropical Medicine and Infectious Disease, Federal University of Triângulo Mineiro, Uberaba/MG, Brazil.