Moderate-Intensity Aerobic Training Program Improves Insulin Sensitivity and Inflammatory Markers in a Pilot Study of Morbidly Obese Minority Teens

in Pediatric Exercise Science
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  • 1 Children’s National Medical Center
  • 2 East Carolina University
  • 3 Georgetown University
  • 4 Duke University Medical Center
  • 5 University of Maryland
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We initiated a pilot study to investigate the effects of 8 wks of aerobic exercise training (ET) on insulin sensitivity and inflammatory markers in obese and insulin-resistant minority adolescents. Eleven morbidly obese (BMI 41.4 ± 1.8 kg/m2) minority adolescents were entered into a supervised ET intervention (~180 min/wk at 40–55%VO2PeakR [(VO2Peak − VO2Rest)/VO2Rest]). The effects of training on insulin sensitivity (SI), inflammation and other metabolic syndrome features were examined. Results: Insulin action improved in response to training, as indicated by a ~37% increase in SI (p = .018). Plasma levels of several proinflammatory cytokines were reduced in response to ET, as indicated by significant decrements in sTNF-R, CCL2, MPO, IL-6, resistin, and leptin, with no significant changes in hsCRP. ET induced reductions in BMI and percent total body fat. Conclusions: The present study supports the efficacy of ET interventions on metabolic syndrome features in morbidly obese minority youth.

Nosotros iniciamos un estudio piloto para investigar los efectos de 8 semanas de entrenamiento con ejercicios aeróbicos (EA) sobre la sensibilidad insulinica y los marcadores inflamatorios en un grupo minoritario de adolescentes abesos con resistencia a lá insulina. Once adolescentes con obesidad mórbida (IMC 41, 4+1.8kg/m2) fueron asignados a un grupo de intervención que realizo un EA supervisado (~180 min/semana al 40-55%VO2 picoR [(VO2Pico − VO2Reposo)/VO2Reposo]). Se analizo el efecto del entrenamiento sobre la sensibilidad insulinica (IS), inflamación y otras características del síndrome metabòlico. RESULATDOS: El incremento del 37% en la SI (p = 0.018) indico que La acción de la insulina mejora en respuesta al entrenamiento. Como indican la disminución significativa de sTNF-R, CCL2, MPO, IL-6, resistina, and leptina, y la falta de cambios significativos en hsCR, los niveles plasmáticos de varias citoquinas proinflamatorias se redujeron en respuesta al EA. Además, el entrenamiento produjo una reducción del IMC y del porcentaje de grasa corporal. CONCLUSIONES: Los resultados del presente estudio apoyan la eficacia de una intervención con EA sobre las características del síndrome metabólico en un grupo minoritario de adolescentes con obesidad mórbida.

Many, Hurtado, Gordish-Dressman, Park, and Hoffman are with the Children’s National Medical Center, Research Center for Genetics Medicine, Washington, DC. Tanner and Houmard are with the Human Performance Laboratory, East Carolina University, Greenville, NC. Uwaifo is with the Dept. of Endocrinology, Georgetown University, Washington, DC. Kraus is with the Center for Living, Duke University Medical Center, Durham, NC. Hagberg is with the Dept. of Kinesiology, University of Maryland, College Park, MD.