Fish Oil Supplementation Reduces Markers of Oxidative Stress But Not Muscle Soreness After Eccentric Exercise

in International Journal of Sport Nutrition and Exercise Metabolism

Click name to view affiliation

Patrick Gray
Search for other papers by Patrick Gray in
Current site
Google Scholar
PubMed
Close
,
Andrew Chappell
Search for other papers by Andrew Chappell in
Current site
Google Scholar
PubMed
Close
,
Alison McE Jenkinson
Search for other papers by Alison McE Jenkinson in
Current site
Google Scholar
PubMed
Close
,
Frank Thies
Search for other papers by Frank Thies in
Current site
Google Scholar
PubMed
Close
, and
Stuart R. Gray
Search for other papers by Stuart R. Gray in
Current site
Google Scholar
PubMed
Close
Restricted access

Due to the potential anti-inflammatory properties of fish-derived long chain n-3 fatty acids, it has been suggested that athletes should regularly consume fish oils—although evidence in support of this recommendation is not clear. While fish oils can positively modulate immune function, it remains possible that, due to their high number of double bonds, there may be concurrent increases in lipid peroxidation. The current study aims to investigate the effect of fish oil supplementation on exercise-induced markers of oxidative stress and muscle damage. Twenty males underwent a 6-week double-blind randomized placebo-controlled supplementation trial involving two groups (fish oil or placebo). After supplementation, participants undertook 200 repetitions of eccentric knee contractions. Blood samples were taken presupplementation, postsupplementation, immediately, 24, 48, and 72 hr postexercise and muscle soreness/maximal voluntary contraction (MVC) assessed. There were no differences in creatine kinase, protein carbonyls, endogenous DNA damage, muscle soreness or MVC between groups. Plasma thiobarbituric acid reactive substances (TBARS) were lower (p < .05) at 48 and 72 hr post exercise and H2O2 stimulated DNA damage was lower (p < .05) immediately postexercise in the fish oil, compared with the control group. The current study demonstrates that fish oil supplementation reduces selected markers of oxidative stress after a single bout of eccentric exercise.

The authors are with the Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.

Address author correspondence to Stuart R. Gray at s.r.gray@abdn.ac.uk.
  • Collapse
  • Expand